Assay Detail
Binding
CHEMBL5142597
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of horse serum BChE using acetylthiocholine iodide or butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition by Ellman's method
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
<i>N</i>-Benzyl Benzamide Derivatives as Selective Sub-Nanomolar Butyrylcholinesterase Inhibitors for Possible Treatment in Advanced Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 8.23 | 10.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5201089 | — | — | 1 | 10.68 |
| CHEMBL5181960 | — | — | 1 | 10.06 |
| CHEMBL5185039 | — | — | 1 | 9.89 |
| CHEMBL5184944 | — | — | 1 | 9.85 |
| CHEMBL5195228 | — | — | 1 | 9.82 |
| CHEMBL5184728 | — | — | 1 | 9.80 |
| CHEMBL5173939 | — | — | 1 | 9.54 |
| CHEMBL5200785 | — | — | 1 | 9.47 |
| CHEMBL5199323 | — | — | 1 | 9.42 |
| CHEMBL5197490 | — | — | 1 | 9.38 |
| CHEMBL5208367 | — | — | 1 | 9.35 |
| CHEMBL5201163 | — | — | 1 | 9.32 |
| CHEMBL5191236 | — | — | 1 | 9.26 |
| CHEMBL5188290 | — | — | 1 | 9.26 |
| CHEMBL5201951 | — | — | 1 | 9.10 |
| CHEMBL5183552 | — | — | 1 | 9.09 |
| CHEMBL5195383 | — | — | 1 | 9.02 |
| CHEMBL5198895 | — | — | 1 | 8.99 |
| CHEMBL5190491 | — | — | 1 | 8.92 |
| CHEMBL5185696 | — | — | 1 | 8.90 |
| CHEMBL5208374 | — | — | 1 | 8.87 |
| CHEMBL5174951 | — | — | 1 | 8.87 |
| CHEMBL5186949 | — | — | 1 | 8.82 |
| CHEMBL5169365 | — | — | 1 | 8.62 |
| CHEMBL5182498 | — | — | 1 | 8.45 |
| CHEMBL5190745 | — | — | 1 | 8.34 |
| CHEMBL5174262 | — | — | 1 | 8.30 |
| CHEMBL5198770 | — | — | 1 | 8.18 |
| CHEMBL5171447 | — | — | 1 | 8.10 |
| CHEMBL5172504 | — | — | 1 | 7.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5201089 | — | IC50 | = | 0.021 | nM | 10.68 |
| CHEMBL5181960 | — | IC50 | = | 0.087 | nM | 10.06 |
| CHEMBL5185039 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL5184944 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL5195228 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL5184728 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL5173939 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL5200785 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL5199323 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL5197490 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL5208367 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL5201163 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL5191236 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL5188290 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL5201951 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL5183552 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL5195383 | — | IC50 | = | 0.96 | nM | 9.02 |
| CHEMBL5198895 | — | IC50 | = | 1.02 | nM | 8.99 |
| CHEMBL5190491 | — | IC50 | = | 1.19 | nM | 8.92 |
| CHEMBL5185696 | — | IC50 | = | 1.27 | nM | 8.90 |
| CHEMBL5174951 | — | IC50 | = | 1.35 | nM | 8.87 |
| CHEMBL5208374 | — | IC50 | = | 1.35 | nM | 8.87 |
| CHEMBL5186949 | — | IC50 | = | 1.51 | nM | 8.82 |
| CHEMBL5169365 | — | IC50 | = | 2.42 | nM | 8.62 |
| CHEMBL5182498 | — | IC50 | = | 3.53 | nM | 8.45 |
| CHEMBL5190745 | — | IC50 | = | 4.55 | nM | 8.34 |
| CHEMBL5174262 | — | IC50 | = | 4.99 | nM | 8.30 |
| CHEMBL5198770 | — | IC50 | = | 6.54 | nM | 8.18 |
| CHEMBL5171447 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL5172504 | — | IC50 | = | 14.37 | nM | 7.84 |
| CHEMBL95 | TACRINE | IC50 | = | 15.22 | nM | 7.82 |
| CHEMBL5195425 | — | IC50 | = | 77.33 | nM | 7.11 |
| CHEMBL5186019 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5178120 | — | IC50 | = | 157.9 | nM | 6.80 |
| CHEMBL5201295 | — | IC50 | = | 186.7 | nM | 6.73 |
| CHEMBL5188959 | — | IC50 | = | 349.6 | nM | 6.46 |
| CHEMBL5185423 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5179673 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL5196163 | — | IC50 | = | 5950.0 | nM | 5.22 |
| CHEMBL5178677 | — | IC50 | = | 12920.0 | nM | 4.89 |
| CHEMBL5185740 | — | IC50 | = | 54970.0 | nM | 4.26 |
| CHEMBL5200557 | — | IC50 | = | 97270.0 | nM | 4.01 |