Assay Detail
Functional
CHEMBL5142938
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tunable Cysteine-Targeting Electrophilic Heteroaromatic Warheads Induce Ferroptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 5.04 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.88 |
| CHEMBL4757878 | — | — | 1 | 5.79 |
| CHEMBL4779501 | — | — | 1 | 5.42 |
| CHEMBL5202037 | — | — | 1 | 5.31 |
| CHEMBL5200648 | — | — | 1 | 5.25 |
| CHEMBL5172310 | — | — | 1 | 5.08 |
| CHEMBL5170991 | — | — | 1 | 5.02 |
| CHEMBL5180667 | — | — | 1 | 4.93 |
| CHEMBL5192347 | — | — | 1 | 4.80 |
| CHEMBL5176803 | — | — | 1 | 4.76 |
| CHEMBL5209317 | — | — | 1 | 4.72 |
| CHEMBL5180216 | — | — | 1 | 4.71 |
| CHEMBL5190989 | — | — | 1 | 4.71 |
| CHEMBL5182154 | — | — | 1 | 4.63 |
| CHEMBL5171004 | — | — | 1 | 4.60 |
| CHEMBL345855 | — | — | 1 | - |
| CHEMBL5169410 | — | — | 1 | - |
| CHEMBL451894 | BENZO[D]OXAZOLE | — | 1 | - |
| CHEMBL510309 | BENZO[D]THIAZOLE | — | 1 | - |
| CHEMBL5189423 | — | — | 1 | - |
| CHEMBL5183555 | — | — | 1 | - |
| CHEMBL4534009 | — | — | 1 | - |
| CHEMBL5195648 | — | — | 1 | - |
| CHEMBL4561532 | — | — | 1 | - |
| CHEMBL5201133 | — | — | 1 | - |
| CHEMBL5176893 | — | — | 1 | - |
| CHEMBL5183191 | — | — | 1 | - |
| CHEMBL5201974 | — | — | 1 | - |
| CHEMBL5172296 | — | — | 1 | - |
| CHEMBL1951048 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL4757878 | — | IC50 | = | 1641.0 | nM | 5.79 |
| CHEMBL4779501 | — | IC50 | = | 3801.0 | nM | 5.42 |
| CHEMBL5202037 | — | IC50 | = | 4880.0 | nM | 5.31 |
| CHEMBL5200648 | — | IC50 | = | 5610.0 | nM | 5.25 |
| CHEMBL5172310 | — | IC50 | = | 8390.0 | nM | 5.08 |
| CHEMBL5170991 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL5180667 | — | IC50 | = | 11610.0 | nM | 4.93 |
| CHEMBL5192347 | — | IC50 | = | 15880.0 | nM | 4.80 |
| CHEMBL5176803 | — | IC50 | = | 17510.0 | nM | 4.76 |
| CHEMBL5209317 | — | IC50 | = | 19160.0 | nM | 4.72 |
| CHEMBL5190989 | — | IC50 | = | 19360.0 | nM | 4.71 |
| CHEMBL5180216 | — | IC50 | = | 19610.0 | nM | 4.71 |
| CHEMBL5182154 | — | IC50 | = | 23180.0 | nM | 4.63 |
| CHEMBL5171004 | — | IC50 | = | 24960.0 | nM | 4.60 |
| CHEMBL5194406 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5185994 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5191061 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL527446 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5170126 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5180349 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5209343 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5178762 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL3181987 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5192339 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5188216 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5172192 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5171341 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5203372 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5196009 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5169715 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5197295 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4534009 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1951048 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5172296 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5201974 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5183191 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5176893 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5201133 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4561532 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5195648 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5201420 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5183555 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5189423 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL510309 | BENZO[D]THIAZOLE | IC50 | > | 40000.0 | nM | - |
| CHEMBL451894 | BENZO[D]OXAZOLE | IC50 | > | 40000.0 | nM | - |
| CHEMBL5169410 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL345855 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5197440 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5188043 | — | IC50 | > | 40000.0 | nM | - |