Assay Detail
Binding
CHEMBL5143776
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR L858R/T790M double mutant (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Emerging Approaches to Overcome Acquired Drug Resistance Obstacles to Osimertinib in Non-Small-Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.48 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4443062 | — | — | 1 | 9.59 |
| CHEMBL4214567 | — | — | 1 | 8.52 |
| CHEMBL5193027 | — | — | 1 | 7.82 |
| CHEMBL4284413 | — | — | 1 | 7.62 |
| CHEMBL4649261 | — | — | 1 | 6.80 |
| CHEMBL4228518 | — | — | 1 | 6.72 |
| CHEMBL5206476 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4443062 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL4214567 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5193027 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4284413 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4649261 | — | IC50 | = | 156.6 | nM | 6.80 |
| CHEMBL4228518 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL5206476 | — | IC50 | = | 5300.0 | nM | 5.28 |