Compound Detail
CHEMBL5206476
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5206476 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SDRVSRIKUIYXKQ-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
401.4
MW (Da)
3.51
ALogP
4
HBA
2
HBD
86.3
PSA (Ų)
0.55
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 5.28 | 5.28 | 5300.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 5300.0 | nM | 5.28 | Inhibition of EGFR L858R/T790M double mutant (unknown origin) | 34323489 |
| Epidermal growth factor receptor | IC50 | = | 5300.0 | nM | 5.28 | Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) | 33243531 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34323489 | 10.1021/acs.jmedchem.1c00876 | Epidermal growth factor receptor | 1 |
| 33243531 | 10.1016/j.ejmech.2020.112995 | Epidermal growth factor receptor | 1 |
| 36375337 | 10.1016/j.ejmech.2022.114889 | Epidermal growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine