Assay Detail
Binding
CHEMBL5215207
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The new opportunities in medicinal chemistry of fourth-generation EGFR inhibitors to overcome C797S mutation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.10 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5220061 | — | — | 1 | 8.12 |
| CHEMBL5218879 | — | — | 1 | 8.05 |
| CHEMBL4228518 | — | — | 1 | 6.94 |
| CHEMBL5206476 | — | — | 1 | 5.28 |
| CHEMBL321494 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5220061 | — | IC50 | = | 7.64 | nM | 8.12 |
| CHEMBL5218879 | — | IC50 | = | 8.83 | nM | 8.05 |
| CHEMBL4228518 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL5206476 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL321494 | — | IC50 | > | 149.0 | nM | - |