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Assay Detail

CHEMBL5143790

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against wild type HIV-1 IIIB infected in human MT4 cells assessed as protection against virus-induced cytopathic effect measured after 5 days by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors.
Zhang X, Sun L, Meuser ME, Zalloum WA, Xu S, Huang T, Cherukupalli S, Jiang X, Ding X, Tao Y, Kang D, De Clercq E, Pannecouque C, Dick A, Cocklin S, Liu X, Zhan P.
Eur J Med Chem (2021) 226 : 113848 -113848
PubMed 34592608 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 17 5.59 6.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4471665 1 6.80
CHEMBL5202526 1 6.24
CHEMBL5191897 1 6.16
CHEMBL1229713 1 6.12
CHEMBL5181328 1 5.83
CHEMBL5202680 1 5.60
CHEMBL5187100 1 5.55
CHEMBL5180695 1 5.45
CHEMBL5176209 1 5.38
CHEMBL5206536 1 5.37
CHEMBL5189572 1 4.51
CHEMBL5191317 1 4.05
CHEMBL5169740 1 -
CHEMBL5192096 1 -
CHEMBL5183344 1 -
CHEMBL5209476 1 -
CHEMBL5207923 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4471665 EC50 = 160.0 nM 6.80
CHEMBL5202526 EC50 = 570.0 nM 6.24
CHEMBL5191897 EC50 = 690.0 nM 6.16
CHEMBL1229713 EC50 = 750.0 nM 6.12
CHEMBL5181328 EC50 = 1480.0 nM 5.83
CHEMBL5202680 EC50 = 2520.0 nM 5.60
CHEMBL5187100 EC50 = 2840.0 nM 5.55
CHEMBL5180695 EC50 = 3590.0 nM 5.45
CHEMBL5176209 EC50 = 4190.0 nM 5.38
CHEMBL5206536 EC50 = 4240.0 nM 5.37
CHEMBL5189572 EC50 = 31070.0 nM 4.51
CHEMBL5191317 EC50 = 89230.0 nM 4.05
CHEMBL5169740 EC50 >= 3670.0 nM -
CHEMBL5192096 EC50 > 32370.0 nM -
CHEMBL5183344 EC50 = 246760.0 nM -
CHEMBL5209476 EC50 > 32650.0 nM -
CHEMBL5207923 EC50 >= 3370.0 nM -