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Assay Detail

CHEMBL5146019

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of JNK3 (unknown origin)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Mitogen-activated protein kinase 10 (CHEMBL2637)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Unraveling the Design and Discovery of c-Jun N-Terminal Kinase Inhibitors and Their Therapeutic Potential in Human Diseases.
Zhu Y, Shuai W, Zhao M, Pan X, Pei J, Wu Y, Bu F, Wang A, Ouyang L, Wang G.
J Med Chem (2022) 65 : 3758 -3775
PubMed 35200035 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 7.20 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4077018 1 9.52
CHEMBL3393607 1 9.12
CHEMBL2216824 1 9.01
CHEMBL5183304 1 7.24
CHEMBL1288160 1 7.11
CHEMBL7064 1 7.05
CHEMBL5193515 1 7.00
CHEMBL5194871 1 6.74
CHEMBL5190624 1 6.64
CHEMBL3393606 1 6.15
CHEMBL5185450 1 5.70
CHEMBL3393605 1 5.11

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4077018 IC50 = 0.3 nM 9.52
CHEMBL3393607 IC50 = 0.75 nM 9.12
CHEMBL2216824 IC50 = 0.98 nM 9.01
CHEMBL5183304 IC50 = 58.17 nM 7.24
CHEMBL1288160 IC50 = 77.0 nM 7.11
CHEMBL7064 IC50 = 90.0 nM 7.05
CHEMBL5193515 IC50 = 99.0 nM 7.00
CHEMBL5194871 IC50 = 184.0 nM 6.74
CHEMBL5190624 IC50 = 227.0 nM 6.64
CHEMBL3393606 IC50 = 709.0 nM 6.15
CHEMBL5185450 IC50 = 2000.0 nM 5.70
CHEMBL3393605 IC50 = 7750.0 nM 5.11