Compound Detail
CHEMBL5194871
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Basic Information
| ChEMBL ID | CHEMBL5194871 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IATSSYNKRCFJAY-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
381.5
MW (Da)
4.08
ALogP
6
HBA
2
HBD
66.1
PSA (Ų)
0.65
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.74
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 10 CHEMBL2637 | IC50 | 6.74 | 6.74 | 184.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 10 | IC50 | = | 184.0 | nM | 6.74 | Inhibition of JNK3 (unknown origin) | 35200035 |
| Mitogen-activated protein kinase 10 | IC50 | = | 184.0 | nM | 6.74 | Inhibition of JNK3 (unknown origin) | 36490325 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35200035 | 10.1021/acs.jmedchem.1c01947 | Mitogen-activated protein kinase 10 | 1 |
| 35200035 | 10.1021/acs.jmedchem.1c01947 | Mitogen-activated protein kinase 14 | 1 |
| 36490325 | 10.1021/acs.jmedchem.2c00799 | Mitogen-activated protein kinase 14 | 1 |
| 36490325 | 10.1021/acs.jmedchem.2c00799 | Mitogen-activated protein kinase 10 | 1 |
Data from ChEMBL 36 via Core Engine