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Assay Detail

CHEMBL5225360

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of JNK3 (unknown origin)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Mitogen-activated protein kinase 10 (CHEMBL2637)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

The Emerging Landscape of Small-Molecule Therapeutics for the Treatment of Huntington's Disease.
Ahamad S, Bhat SA.
J Med Chem (2022) 65 : 15993 -16032
PubMed 36490325 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 7.30 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4077018 1 9.52
CHEMBL5271950 1 8.33
CHEMBL3394106 1 7.75
CHEMBL4074524 1 7.62
CHEMBL5287474 1 7.58
CHEMBL5284967 1 7.32
CHEMBL5274433 1 7.13
CHEMBL5281537 1 7.03
CHEMBL524174 1 6.74
CHEMBL5194871 1 6.74
CHEMBL426183 1 6.70
CHEMBL5269500 1 6.36
CHEMBL10 SB-203580 1 6.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4077018 IC50 = 0.3 nM 9.52
CHEMBL5271950 IC50 = 4.7 nM 8.33
CHEMBL3394106 IC50 = 18.0 nM 7.75
CHEMBL4074524 IC50 = 24.0 nM 7.62
CHEMBL5287474 IC50 = 26.0 nM 7.58
CHEMBL5284967 IC50 = 48.0 nM 7.32
CHEMBL5274433 IC50 = 74.0 nM 7.13
CHEMBL5281537 IC50 = 94.0 nM 7.03
CHEMBL524174 IC50 = 181.0 nM 6.74
CHEMBL5194871 IC50 = 184.0 nM 6.74
CHEMBL426183 IC50 = 202.0 nM 6.70
CHEMBL5269500 IC50 = 433.0 nM 6.36
CHEMBL10 SB-203580 IC50 = 720.0 nM 6.14