Compound Detail
CHEMBL5271950
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5271950 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CGNKYRTVBHREGA-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
345.4
MW (Da)
4.60
ALogP
4
HBA
3
HBD
79.6
PSA (Ų)
0.47
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.33
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 10 CHEMBL2637 | IC50 | 8.33 | 8.33 | 4.7 | 1 |
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 8.12 | 8.12 | 7.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 10 | IC50 | = | 4.7 | nM | 8.33 | Inhibition of JNK3 (unknown origin) | 36490325 |
| Mitogen-activated protein kinase 14 | IC50 | = | 7.5 | nM | 8.12 | Inhibition of p38alpha (unknown origin) | 36490325 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36490325 | 10.1021/acs.jmedchem.2c00799 | Mitogen-activated protein kinase 14 | 1 |
| 36490325 | 10.1021/acs.jmedchem.2c00799 | Mitogen-activated protein kinase 10 | 1 |
Data from ChEMBL 36 via Core Engine