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Assay Detail

CHEMBL5149845

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Functional
Antiproliferative activity against human A375 cells assessed as reduction in cell viability incubated for 72 hrs by trypan blue or crystal violet staining based assay
ChEMBL ↗
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A-375
Confidence 1 — Organism
Curated By Autocuration

Target

A-375 (CHEMBL613859) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Quinolines and Oxazino-quinoline Derivatives as Small Molecule GLI1 Inhibitors Identified by Virtual Screening.
Manetti F, Maresca L, Crivaro E, Pepe S, Cini E, Singh S, Governa P, Maramai S, Giannini G, Stecca B, Petricci E.
ACS Med Chem Lett (2022) 13 : 1329 -1336
PubMed 35978701 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 44 6.56 7.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5189017 — — 1 7.05
CHEMBL592116 — — 1 7.00
CHEMBL607140 — — 1 6.96
CHEMBL1332404 — — 1 6.96
CHEMBL5180990 — — 1 6.92
CHEMBL5186150 — — 1 6.92
CHEMBL5174265 — — 1 6.92
CHEMBL592092 — — 1 6.92
CHEMBL5169431 — — 1 6.89
CHEMBL5187152 — — 1 6.89
CHEMBL5198250 — — 1 6.89
CHEMBL608561 — — 1 6.89
CHEMBL5193890 — — 1 6.89
CHEMBL5206033 — — 1 6.82
CHEMBL5193642 — — 1 6.72
CHEMBL5180327 — — 1 6.55
CHEMBL5209473 — — 1 6.52
CHEMBL5182495 — — 1 6.52
CHEMBL5172801 — — 1 6.50
CHEMBL5202174 — — 1 6.50
CHEMBL5199077 — — 1 6.42
CHEMBL5170312 — — 1 6.41
CHEMBL5183321 — — 1 6.38
CHEMBL5170490 — — 1 6.31
CHEMBL5184596 — — 1 6.30
CHEMBL5171173 — — 1 6.27
CHEMBL5195320 — — 1 6.26
CHEMBL5170369 — — 1 6.24
CHEMBL1514530 — — 1 6.15
CHEMBL5180029 — — 1 6.06

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5189017 — IC50 = 90.0 nM 7.05
CHEMBL592116 — IC50 = 100.0 nM 7.00
CHEMBL1332404 — IC50 = 110.0 nM 6.96
CHEMBL607140 — IC50 = 110.0 nM 6.96
CHEMBL5180990 — IC50 = 120.0 nM 6.92
CHEMBL5186150 — IC50 = 120.0 nM 6.92
CHEMBL5174265 — IC50 = 120.0 nM 6.92
CHEMBL592092 — IC50 = 120.0 nM 6.92
CHEMBL5193890 — IC50 = 130.0 nM 6.89
CHEMBL608561 — IC50 = 130.0 nM 6.89
CHEMBL5198250 — IC50 = 130.0 nM 6.89
CHEMBL5187152 — IC50 = 130.0 nM 6.89
CHEMBL5169431 — IC50 = 130.0 nM 6.89
CHEMBL5206033 — IC50 = 150.0 nM 6.82
CHEMBL5193642 — IC50 = 190.0 nM 6.72
CHEMBL5180327 — IC50 = 280.0 nM 6.55
CHEMBL5209473 — IC50 = 300.0 nM 6.52
CHEMBL5182495 — IC50 = 300.0 nM 6.52
CHEMBL5172801 — IC50 = 320.0 nM 6.50
CHEMBL5202174 — IC50 = 320.0 nM 6.50
CHEMBL5199077 — IC50 = 380.0 nM 6.42
CHEMBL5170312 — IC50 = 390.0 nM 6.41
CHEMBL5183321 — IC50 = 420.0 nM 6.38
CHEMBL5170490 — IC50 = 490.0 nM 6.31
CHEMBL5184596 — IC50 = 500.0 nM 6.30
CHEMBL5171173 — IC50 = 540.0 nM 6.27
CHEMBL5195320 — IC50 = 550.0 nM 6.26
CHEMBL5170369 — IC50 = 580.0 nM 6.24
CHEMBL1514530 — IC50 = 710.0 nM 6.15
CHEMBL5180029 — IC50 = 880.0 nM 6.06
CHEMBL5186329 — IC50 = 910.0 nM 6.04
CHEMBL5201340 — IC50 = 1010.0 nM 6.00
CHEMBL5194280 — IC50 = 1100.0 nM 5.96
CHEMBL590665 — IC50 = 1120.0 nM 5.95
CHEMBL5172660 — IC50 - — -
CHEMBL5174491 — IC50 - — -
CHEMBL5175343 — IC50 - — -
CHEMBL225164 CLOXYQUIN IC50 - — -
CHEMBL5175934 — IC50 - — -
CHEMBL5203258 — IC50 - — -
CHEMBL1370278 — IC50 - — -
CHEMBL5183706 — IC50 - — -
CHEMBL5182211 — IC50 - — -
CHEMBL5194611 — IC50 - — -