Assay Detail
Binding
CHEMBL5149904
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human isoQC using H-Gln-AMC hydrobromide as fluorogenic substrate incubated for 6 hrs by fluorometric microplate reader analysis
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutaminyl-peptide cyclotransferase-like protein (CHEMBL3638349) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-Amino-1,3,4-thiadiazoles as Glutaminyl Cyclases Inhibitors Increase Phagocytosis through Modification of CD47-SIRPα Checkpoint.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.51 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5193156 | — | — | 1 | 7.14 |
| CHEMBL5202172 | — | — | 1 | 7.14 |
| CHEMBL5204178 | — | — | 1 | 6.98 |
| CHEMBL5174554 | — | — | 1 | 6.82 |
| CHEMBL5195495 | — | — | 1 | 6.80 |
| CHEMBL5190683 | — | — | 1 | 6.76 |
| CHEMBL5202004 | — | — | 1 | 6.76 |
| CHEMBL5181839 | — | — | 1 | 6.70 |
| CHEMBL5197396 | — | — | 1 | 6.66 |
| CHEMBL5207620 | — | — | 1 | 6.62 |
| CHEMBL5194983 | — | — | 1 | 6.53 |
| CHEMBL5181626 | — | — | 1 | 6.53 |
| CHEMBL5186970 | — | — | 1 | 6.47 |
| CHEMBL201747 | — | — | 1 | 6.46 |
| CHEMBL5178150 | — | — | 1 | 6.45 |
| CHEMBL5174441 | — | — | 1 | 6.45 |
| CHEMBL5188828 | — | — | 1 | 6.38 |
| CHEMBL5187305 | — | — | 1 | 6.29 |
| CHEMBL5205052 | — | — | 1 | 5.90 |
| CHEMBL5198938 | — | — | 1 | 5.72 |
| CHEMBL5175865 | — | — | 1 | 5.15 |
| CHEMBL5182535 | — | — | 1 | - |
| CHEMBL5185768 | — | — | 1 | - |
| CHEMBL275066 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5193156 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL5202172 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL5204178 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL5174554 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL5195495 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL5190683 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL5202004 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL5181839 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL5197396 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL5207620 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL5194983 | — | IC50 | = | 297.0 | nM | 6.53 |
| CHEMBL5181626 | — | IC50 | = | 298.0 | nM | 6.53 |
| CHEMBL5186970 | — | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL201747 | — | IC50 | = | 351.0 | nM | 6.46 |
| CHEMBL5178150 | — | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL5174441 | — | IC50 | = | 353.0 | nM | 6.45 |
| CHEMBL5188828 | — | IC50 | = | 414.0 | nM | 6.38 |
| CHEMBL5187305 | — | IC50 | = | 514.0 | nM | 6.29 |
| CHEMBL5205052 | — | IC50 | = | 1249.0 | nM | 5.90 |
| CHEMBL5198938 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5175865 | — | IC50 | = | 7028.0 | nM | 5.15 |
| CHEMBL5182535 | — | IC50 | - | — | - | |
| CHEMBL5185768 | — | IC50 | - | — | - | |
| CHEMBL275066 | — | IC50 | - | — | - |