Compound Detail
CHEMBL5193156
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Basic Information
| ChEMBL ID | CHEMBL5193156 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VXNMURILOSNNJI-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
478.6
MW (Da)
4.45
ALogP
9
HBA
1
HBD
91.3
PSA (Ų)
0.36
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutaminyl-peptide cyclotransferase CHEMBL4508 | IC50 | 7.92 | 7.92 | 12.0 | 2 |
| Glutaminyl-peptide cyclotransferase-like protein CHEMBL3638349 | IC50 | 7.14 | 7.14 | 73.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutaminyl-peptide cyclotransferase | IC50 | = | 12.0 | nM | 7.92 | Inhibition of recombinant human QC using H-Gln-AMC hydrobromide as fluorogenic s... | 36105338 |
| Glutaminyl-peptide cyclotransferase | IC50 | = | 12.0 | nM | 7.92 | Inhibition of sQC (unknown origin) expressed in Escherichia coli Transetta (DE3)... | 38817193 |
| Glutaminyl-peptide cyclotransferase-like protein | IC50 | = | 73.0 | nM | 7.14 | Inhibition of recombinant human isoQC using H-Gln-AMC hydrobromide as fluorogeni... | 36105338 |
| Glutaminyl-peptide cyclotransferase-like protein | IC50 | = | 73.0 | nM | 7.14 | Inhibition of gQC (unknown origin) expressed in Escherichia coli Transetta (DE3)... | 38817193 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36105338 | 10.1021/acsmedchemlett.2c00256 | Unchecked | 4 |
| 36105338 | 10.1021/acsmedchemlett.2c00256 | A549 | 3 |
| 36105338 | 10.1021/acsmedchemlett.2c00256 | NCI-H1975 | 3 |
| 36105338 | 10.1021/acsmedchemlett.2c00256 | Glutaminyl-peptide cyclotransferase-like protein | 1 |
| 36105338 | 10.1021/acsmedchemlett.2c00256 | Glutaminyl-peptide cyclotransferase | 1 |
| 38817193 | 10.1021/acs.jmedchem.4c00049 | Glutaminyl-peptide cyclotransferase | 1 |
| 38817193 | 10.1021/acs.jmedchem.4c00049 | Glutaminyl-peptide cyclotransferase-like protein | 1 |
Data from ChEMBL 36 via Core Engine