Assay Detail
Binding
CHEMBL5149905
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human QC using H-Gln-AMC hydrobromide as fluorogenic substrate incubated for 6 hrs by fluorometric microplate reader analysis
69
Total Activities
69
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Amino-1,3,4-thiadiazoles as Glutaminyl Cyclases Inhibitors Increase Phagocytosis through Modification of CD47-SIRPα Checkpoint.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 69 | 6.46 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5193156 | — | — | 1 | 7.92 |
| CHEMBL5190683 | — | — | 1 | 7.77 |
| CHEMBL5181839 | — | — | 1 | 7.75 |
| CHEMBL5202172 | — | — | 1 | 7.70 |
| CHEMBL201747 | — | — | 1 | 7.54 |
| CHEMBL5195495 | — | — | 1 | 7.24 |
| CHEMBL5197396 | — | — | 1 | 7.01 |
| CHEMBL5207620 | — | — | 1 | 7.00 |
| CHEMBL5194983 | — | — | 1 | 6.97 |
| CHEMBL5202004 | — | — | 1 | 6.96 |
| CHEMBL5178150 | — | — | 1 | 6.93 |
| CHEMBL5204178 | — | — | 1 | 6.81 |
| CHEMBL5186970 | — | — | 1 | 6.80 |
| CHEMBL5198938 | — | — | 1 | 6.77 |
| CHEMBL5174441 | — | — | 1 | 6.72 |
| CHEMBL5174554 | — | — | 1 | 6.70 |
| CHEMBL5175865 | — | — | 1 | 6.70 |
| CHEMBL5188828 | — | — | 1 | 6.30 |
| CHEMBL5205052 | — | — | 1 | 6.30 |
| CHEMBL5187305 | — | — | 1 | 6.22 |
| CHEMBL5194144 | — | — | 1 | 5.82 |
| CHEMBL5196820 | — | — | 1 | 5.80 |
| CHEMBL5186424 | — | — | 1 | 5.75 |
| CHEMBL5183220 | — | — | 1 | 5.68 |
| CHEMBL5181626 | — | — | 1 | 5.66 |
| CHEMBL5169588 | — | — | 1 | 5.60 |
| CHEMBL5172975 | — | — | 1 | 5.47 |
| CHEMBL5196169 | — | — | 1 | 5.44 |
| CHEMBL5194882 | — | — | 1 | 5.42 |
| CHEMBL5196273 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5193156 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5190683 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5181839 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5202172 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL201747 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5195495 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5197396 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL5207620 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5194983 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL5202004 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL5178150 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL5204178 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL5186970 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5198938 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5174441 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5174554 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL5175865 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5188828 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5205052 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5187305 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5194144 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5196820 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5186424 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5183220 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL5181626 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL5169588 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5172975 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5196169 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5194882 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL5196273 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5201318 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL280998 | CATECHOL | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL81398 | — | IC50 | = | 353000.0 | nM | - |
| CHEMBL5173734 | — | IC50 | - | — | - | |
| CHEMBL52209 | — | IC50 | = | 772000.0 | nM | - |
| CHEMBL70927 | DEFERIPRONE | IC50 | - | — | - | |
| CHEMBL1235568 | — | IC50 | - | — | - | |
| CHEMBL1649594 | — | IC50 | - | — | - | |
| CHEMBL5194795 | — | IC50 | - | — | - | |
| CHEMBL1650621 | — | IC50 | - | — | - | |
| CHEMBL1650620 | — | IC50 | - | — | - | |
| CHEMBL61236 | — | IC50 | - | — | - | |
| CHEMBL310555 | OXYQUINOLINE | IC50 | = | 208000.0 | nM | - |
| CHEMBL1368601 | — | IC50 | = | 203000.0 | nM | - |
| CHEMBL99932 | 8-AMINOQUINOLINE | IC50 | - | — | - | |
| CHEMBL79857 | — | IC50 | = | 232000.0 | nM | - |
| CHEMBL275066 | — | IC50 | - | — | - | |
| CHEMBL5185768 | — | IC50 | = | 144000.0 | nM | - |
| CHEMBL5182535 | — | IC50 | - | — | - | |
| CHEMBL574699 | BARBITURIC ACID | IC50 | - | — | - |