Assay Detail
Functional
CHEMBL5149933
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Antiproliferative activity against human A2780 cells incubated for 72 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Aroylhydrazone Glycoconjugate Prochelators Exploit Glucose Transporter 1 (GLUT1) to Target Iron in Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.46 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5180723 | — | — | 1 | 5.68 |
| CHEMBL5198095 | — | — | 1 | 5.60 |
| CHEMBL556 | DEFEROXAMINE | 4.0 | 1 | 5.46 |
| CHEMBL5188074 | — | — | 1 | 5.28 |
| CHEMBL5196995 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5180723 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5198095 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL556 | DEFEROXAMINE | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5188074 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5196995 | — | IC50 | = | 5300.0 | nM | 5.28 |