Assay Detail
Binding
CHEMBL5150292
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ROCK1 (unknown origin)
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.08 | 9.00 |
| IC50 | 3 | 7.56 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4594250 | NETARSUDIL | 4.0 | 1 | 9.00 |
| CHEMBL3545065 | VEROSUDIL | 2.0 | 1 | 8.70 |
| CHEMBL5182402 | — | — | 1 | 8.30 |
| CHEMBL4438748 | — | — | 1 | 7.82 |
| CHEMBL571948 | Y-39983 | 1.0 | 1 | 7.55 |
| CHEMBL3426621 | RIPASUDIL | 3.0 | 1 | 7.29 |
| CHEMBL559147 | Y-27632 | — | 1 | 6.85 |
| CHEMBL2005186 | BELUMOSUDIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4594250 | NETARSUDIL | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL3545065 | VEROSUDIL | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL5182402 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL4438748 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL571948 | Y-39983 | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL3426621 | RIPASUDIL | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL559147 | Y-27632 | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL2005186 | BELUMOSUDIL | IC50 | > | 10000.0 | nM | - |