Assay Detail
Binding
CHEMBL5151003
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Notum using OPTS substrate by fluorescence based assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Palmitoleoyl-protein carboxylesterase NOTUM (CHEMBL3714531) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.64 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3760062 | — | — | 1 | 9.40 |
| CHEMBL3774760 | — | — | 1 | 9.00 |
| CHEMBL3774528 | — | — | 1 | 8.70 |
| CHEMBL4174188 | — | — | 1 | 6.77 |
| CHEMBL284521 | — | — | 1 | 4.43 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 4.12 |
| CHEMBL33103 | ACETYLSEROTONIN | — | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3760062 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3774760 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3774528 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4174188 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL284521 | — | IC50 | = | 37200.0 | nM | 4.43 |
| CHEMBL45 | MELATONIN | IC50 | = | 75400.0 | nM | 4.12 |
| CHEMBL33103 | ACETYLSEROTONIN | IC50 | = | 93600.0 | nM | 4.03 |