Assay Detail
Binding
CHEMBL5153399
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membrane
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Pyrazole-containing pharmaceuticals: target, pharmacological activity, and their SAR studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.71 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93226 | — | — | 1 | 9.46 |
| CHEMBL332897 | — | — | 1 | 9.26 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93226 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL332897 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL191 | LOSARTAN | IC50 | = | 40.0 | nM | 7.40 |