Assay Detail
Functional
CHEMBL5153644
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Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of Fibroblast Growth Factor Receptor (FGFR) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.11 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5186645 | — | — | 1 | 8.52 |
| CHEMBL5198510 | — | — | 1 | 8.00 |
| CHEMBL5202576 | — | — | 1 | 8.00 |
| CHEMBL3545376 | ERDAFITINIB | 4.0 | 1 | 7.70 |
| CHEMBL5178408 | — | — | 1 | 7.70 |
| CHEMBL5191744 | — | — | 1 | 7.70 |
| CHEMBL5173348 | — | — | 1 | 7.52 |
| CHEMBL5170945 | — | — | 1 | 7.40 |
| CHEMBL5186714 | — | — | 1 | 7.40 |
| CHEMBL5206740 | — | — | 1 | 7.40 |
| CHEMBL5177696 | — | — | 1 | 7.40 |
| CHEMBL5181688 | — | — | 1 | 7.22 |
| CHEMBL5179871 | — | — | 1 | 7.22 |
| CHEMBL5204809 | — | — | 1 | 6.80 |
| CHEMBL5187998 | — | — | 1 | 6.70 |
| CHEMBL5202912 | — | — | 1 | 6.70 |
| CHEMBL5203230 | — | — | 1 | 6.70 |
| CHEMBL5170820 | — | — | 1 | 6.60 |
| CHEMBL5182360 | — | — | 1 | 6.58 |
| CHEMBL5170264 | — | — | 1 | 6.58 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.37 |
| CHEMBL5179314 | — | — | 1 | 6.33 |
| CHEMBL5199914 | — | — | 1 | 6.23 |
| CHEMBL5183668 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5186645 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5198510 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5202576 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3545376 | ERDAFITINIB | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5178408 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5191744 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5173348 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5170945 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5186714 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5206740 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5177696 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5181688 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5179871 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5204809 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5187998 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5202912 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5203230 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5170820 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5182360 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5170264 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5179314 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL5199914 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL5183668 | — | IC50 | = | 1460.0 | nM | 5.84 |