Assay Detail
Binding
CHEMBL5159012
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Inhibition of AURB (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Aurora A and Protein Kinase C (α, β1, β2, and θ) Multitarget Inhibitors: Impact of Selenium Atoms on the Potency and Selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.52 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1090479 | GSK-1070916 | 1.0 | 1 | 8.30 |
| CHEMBL482967 | CYC-116 | 1.0 | 1 | 8.04 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 7.75 |
| CHEMBL482767 | SNS-314 | 1.0 | 1 | 7.51 |
| CHEMBL402548 | DANUSERTIB | 2.0 | 1 | 7.10 |
| CHEMBL483158 | ALISERTIB | 3.0 | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1090479 | GSK-1070916 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL482967 | CYC-116 | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL482767 | SNS-314 | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL402548 | DANUSERTIB | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL483158 | ALISERTIB | IC50 | = | 396.0 | nM | 6.40 |