Assay Detail
Functional
CHEMBL5159113
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Antitrypanosomal activity against Trypanosoma brucei incubated for 72 hrs by alamar blue dye based fluorimetry analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Thiosugar naphthalene diimide conjugates: G-quadruplex ligands with antiparasitic and anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.63 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5174664 | — | — | 1 | 7.40 |
| CHEMBL5207677 | — | — | 1 | 7.30 |
| CHEMBL5172848 | — | — | 1 | 7.30 |
| CHEMBL4095443 | — | — | 1 | 7.30 |
| CHEMBL5195378 | — | — | 1 | 7.22 |
| CHEMBL5170475 | — | — | 1 | 7.22 |
| CHEMBL5198659 | — | — | 1 | 7.10 |
| CHEMBL4068055 | — | — | 1 | 7.10 |
| CHEMBL5183586 | — | — | 1 | 6.82 |
| CHEMBL5187011 | — | — | 1 | 6.51 |
| CHEMBL5183131 | — | — | 1 | 6.14 |
| CHEMBL5180970 | — | — | 1 | 6.07 |
| CHEMBL5173053 | — | — | 1 | 5.93 |
| CHEMBL5193069 | — | — | 1 | 5.68 |
| CHEMBL5172630 | — | — | 1 | 5.52 |
| CHEMBL5199159 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5174664 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5207677 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5172848 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4095443 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5195378 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5170475 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5198659 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4068055 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5183586 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5187011 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5183131 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL5180970 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL5173053 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL5193069 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5172630 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL5199159 | — | IC50 | = | 3320.0 | nM | 5.48 |