Assay Detail
Binding
CHEMBL5160211
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of ATM (unknown origin) measured by ATP-competitive binding assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel ataxia telangiectasia mutated (ATM) kinase modulators: Computational simulation, biological evaluation and cancer combinational chemotherapy study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.49 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3960662 | — | — | 1 | 9.24 |
| CHEMBL4594429 | AZD-1390 | 1.0 | 1 | 9.11 |
| CHEMBL4218734 | — | — | 1 | 7.34 |
| CHEMBL2140173 | — | — | 1 | 7.22 |
| CHEMBL222102 | KU-55933 | — | 1 | 6.60 |
| CHEMBL5178407 | — | — | 1 | 6.51 |
| CHEMBL2143829 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3960662 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL4594429 | AZD-1390 | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL4218734 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL2140173 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL222102 | KU-55933 | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5178407 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL2143829 | — | IC50 | = | 370.0 | nM | 6.43 |