Assay Detail
Functional
CHEMBL5162919
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Antiproliferative activity against human THP-1 cells assessed as cell growth inhibition measured upto 4 hrs by CellTiter-Blue cell viability assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 2H-Imidazo[2',1':2,3] [1,3]thiazolo[4,5-e]isoindol-8-yl-phenylureas with promising therapeutic features for the treatment of acute myeloid leukemia (AML) with FLT3/ITD mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.29 | 5.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5169362 | — | — | 1 | 5.87 |
| CHEMBL5205434 | — | — | 1 | 5.86 |
| CHEMBL5183674 | — | — | 1 | 5.84 |
| CHEMBL522892 | DOVITINIB | 3.0 | 1 | 5.71 |
| CHEMBL5185748 | — | — | 1 | 5.70 |
| CHEMBL5206333 | — | — | 1 | 5.64 |
| CHEMBL5189185 | — | — | 1 | 5.61 |
| CHEMBL5173972 | — | — | 1 | 5.59 |
| CHEMBL5190625 | — | — | 1 | 5.57 |
| CHEMBL5184524 | — | — | 1 | 5.55 |
| CHEMBL5209513 | — | — | 1 | 5.34 |
| CHEMBL5198100 | — | — | 1 | 5.28 |
| CHEMBL5199887 | — | — | 1 | 5.16 |
| CHEMBL5188083 | — | — | 1 | 5.08 |
| CHEMBL5205101 | — | — | 1 | 4.89 |
| CHEMBL5177051 | — | — | 1 | 4.83 |
| CHEMBL5207842 | — | — | 1 | 4.71 |
| CHEMBL5207705 | — | — | 1 | 4.68 |
| CHEMBL5176979 | — | — | 1 | 4.59 |
| CHEMBL5207335 | — | — | 1 | 4.27 |
| CHEMBL576982 | QUIZARTINIB | 4.0 | 1 | - |
| CHEMBL210833 | — | — | 1 | - |
| CHEMBL5202676 | — | — | 1 | - |
| CHEMBL5173318 | — | — | 1 | - |
| CHEMBL5177337 | — | — | 1 | - |
| CHEMBL5173261 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5169362 | — | IC50 | = | 1361.0 | nM | 5.87 |
| CHEMBL5205434 | — | IC50 | = | 1375.0 | nM | 5.86 |
| CHEMBL5183674 | — | IC50 | = | 1454.0 | nM | 5.84 |
| CHEMBL522892 | DOVITINIB | IC50 | = | 1936.0 | nM | 5.71 |
| CHEMBL5185748 | — | IC50 | = | 1985.0 | nM | 5.70 |
| CHEMBL5206333 | — | IC50 | = | 2271.0 | nM | 5.64 |
| CHEMBL5189185 | — | IC50 | = | 2438.0 | nM | 5.61 |
| CHEMBL5173972 | — | IC50 | = | 2539.0 | nM | 5.59 |
| CHEMBL5190625 | — | IC50 | = | 2675.0 | nM | 5.57 |
| CHEMBL5184524 | — | IC50 | = | 2798.0 | nM | 5.55 |
| CHEMBL5209513 | — | IC50 | = | 4519.0 | nM | 5.34 |
| CHEMBL5198100 | — | IC50 | = | 5201.0 | nM | 5.28 |
| CHEMBL5199887 | — | IC50 | = | 6945.0 | nM | 5.16 |
| CHEMBL5188083 | — | IC50 | = | 8288.0 | nM | 5.08 |
| CHEMBL5205101 | — | IC50 | = | 12920.0 | nM | 4.89 |
| CHEMBL5177051 | — | IC50 | = | 14620.0 | nM | 4.83 |
| CHEMBL5207842 | — | IC50 | = | 19641.0 | nM | 4.71 |
| CHEMBL5207705 | — | IC50 | = | 20930.0 | nM | 4.68 |
| CHEMBL5176979 | — | IC50 | = | 25404.0 | nM | 4.59 |
| CHEMBL5207335 | — | IC50 | = | 53750.0 | nM | 4.27 |
| CHEMBL576982 | QUIZARTINIB | IC50 | > | 100000.0 | nM | - |
| CHEMBL210833 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5202676 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5173318 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5177337 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5173261 | — | IC50 | > | 100000.0 | nM | - |