Assay Detail
Binding
CHEMBL5165150
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Inhibition of SERT (unknown origin) expressed in human HEK293 cells
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer's disease and depression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.84 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439849 | VILAZODONE | 4.0 | 1 | 9.40 |
| CHEMBL5176363 | — | — | 1 | 8.36 |
| CHEMBL5191418 | — | — | 1 | 8.36 |
| CHEMBL5180472 | — | — | 1 | 8.34 |
| CHEMBL5181226 | — | — | 1 | 8.30 |
| CHEMBL5184959 | — | — | 1 | 8.19 |
| CHEMBL5170075 | — | — | 1 | 8.17 |
| CHEMBL5175011 | — | — | 1 | 8.13 |
| CHEMBL5208902 | — | — | 1 | 8.11 |
| CHEMBL5183093 | — | — | 1 | 8.09 |
| CHEMBL5201565 | — | — | 1 | 7.95 |
| CHEMBL5207117 | — | — | 1 | 7.93 |
| CHEMBL5170676 | — | — | 1 | 7.86 |
| CHEMBL5183581 | — | — | 1 | 7.85 |
| CHEMBL5180815 | — | — | 1 | 7.82 |
| CHEMBL5173093 | — | — | 1 | 7.72 |
| CHEMBL5203206 | — | — | 1 | 7.51 |
| CHEMBL5200156 | — | — | 1 | 7.38 |
| CHEMBL5204395 | — | — | 1 | 7.34 |
| CHEMBL5194592 | — | — | 1 | 7.24 |
| CHEMBL5188606 | — | — | 1 | 7.18 |
| CHEMBL5192104 | — | — | 1 | 7.17 |
| CHEMBL5170867 | — | — | 1 | 5.92 |
| CHEMBL5178292 | — | — | 1 | - |
| CHEMBL5172714 | — | — | 1 | - |
| CHEMBL3989929 | AZELIRAGON | 3.0 | 1 | - |
| CHEMBL5178447 | — | — | 1 | - |
| CHEMBL5204858 | — | — | 1 | - |
| CHEMBL5199141 | — | — | 1 | - |
| CHEMBL5174761 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439849 | VILAZODONE | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5176363 | — | IC50 | = | 4.36 | nM | 8.36 |
| CHEMBL5191418 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL5180472 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL5181226 | — | IC50 | = | 4.97 | nM | 8.30 |
| CHEMBL5184959 | — | IC50 | = | 6.42 | nM | 8.19 |
| CHEMBL5170075 | — | IC50 | = | 6.71 | nM | 8.17 |
| CHEMBL5175011 | — | IC50 | = | 7.47 | nM | 8.13 |
| CHEMBL5208902 | — | IC50 | = | 7.77 | nM | 8.11 |
| CHEMBL5183093 | — | IC50 | = | 8.23 | nM | 8.09 |
| CHEMBL5201565 | — | IC50 | = | 11.16 | nM | 7.95 |
| CHEMBL5207117 | — | IC50 | = | 11.67 | nM | 7.93 |
| CHEMBL5170676 | — | IC50 | = | 13.83 | nM | 7.86 |
| CHEMBL5183581 | — | IC50 | = | 14.17 | nM | 7.85 |
| CHEMBL5180815 | — | IC50 | = | 15.05 | nM | 7.82 |
| CHEMBL5173093 | — | IC50 | = | 18.9 | nM | 7.72 |
| CHEMBL5203206 | — | IC50 | = | 31.09 | nM | 7.51 |
| CHEMBL5200156 | — | IC50 | = | 41.58 | nM | 7.38 |
| CHEMBL5204395 | — | IC50 | = | 45.83 | nM | 7.34 |
| CHEMBL5194592 | — | IC50 | = | 57.73 | nM | 7.24 |
| CHEMBL5188606 | — | IC50 | = | 65.58 | nM | 7.18 |
| CHEMBL5192104 | — | IC50 | = | 67.83 | nM | 7.17 |
| CHEMBL5170867 | — | IC50 | = | 1206.0 | nM | 5.92 |
| CHEMBL5170035 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5177452 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5206806 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5208411 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5196372 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5172417 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5174761 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5199141 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5204858 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5178447 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3989929 | AZELIRAGON | IC50 | > | 3000.0 | nM | - |
| CHEMBL5172714 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5178292 | — | IC50 | > | 100.0 | nM | - |