Assay Detail
Binding
CHEMBL5167555
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal Flag-GFP-TEV site-Met48 recombinant pig gastric H(+)/K(+) ATPase alpha A339S mutant/beta subunit activity in HEK293 cells by colorimetric microplate reader
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.88 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105502 | SORAPRAZAN | 2.0 | 1 | 6.54 |
| CHEMBL47529 | — | — | 1 | 6.00 |
| CHEMBL1618279 | REVAPRAZAN | 2.0 | 1 | 5.96 |
| CHEMBL4297583 | TEGOPRAZAN | 3.0 | 1 | 5.75 |
| CHEMBL5208003 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105502 | SORAPRAZAN | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL47529 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1618279 | REVAPRAZAN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4297583 | TEGOPRAZAN | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5208003 | — | IC50 | = | 7200.0 | nM | 5.14 |