Compound Detail
CHEMBL4297583
TEGOPRAZAN 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL4297583 |
| Name | TEGOPRAZAN |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | CLIQCDHNPDMGSL-HNNXBMFYSA-N |
1
Targets
8
Activities
1
Assay Types
0
PK Parameters
1
Publications
3
Known Names
7
Indications
1
Mechanisms
Molecular Properties
387.4
MW (Da)
3.75
ALogP
4
HBA
1
HBD
67.5
PSA (Ų)
0.74
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Potassium-transporting ATPase blocker | BLOCKER | Potassium-transporting ATPase | ✓ | ✓ |
Indications
Duodenal Ulcer Gastroesophageal Reflux Helicobacter Infections Laryngopharyngeal Reflux Peptic Ulcer Stomach Ulcer Liver Diseases
ATC Classification
A02BC09
tegoprazan
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: DRUGS FOR ACID RELATED DISORDERS
Activity Summary
IC50 8 meas. best 5.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.75 | 4.9729 | 1800.0 | 7 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 1800.0 | nM | 5.75 | Inhibition of N-terminal Flag-GFP-TEV site-Met48 recombinant pig gastric H(+)/K(... | 35604136 |
| Unchecked | IC50 | = | 2300.0 | nM | 5.64 | Inhibition of N-terminal Flag-GFP-TEV site-Met48 recombinant pig gastric H(+)/K(... | 35604136 |
| Unchecked | IC50 | = | 6700.0 | nM | 5.17 | Inhibition of N-terminal Flag-GFP-TEV site-Met48 recombinant pig gastric H(+)/K(... | 35604136 |
| Unchecked | IC50 | = | 7300.0 | nM | 5.14 | Inhibition of N-terminal Flag-GFP-TEV site-Met48 recombinant pig gastric H(+)/K(... | 35604136 |
| Unchecked | IC50 | = | 33000.0 | nM | 4.48 | Inhibition of N-terminal Flag-GFP-TEV site-Met48 recombinant pig gastric H(+)/K(... | 35604136 |
| Unchecked | IC50 | = | 38000.0 | nM | 4.42 | Inhibition of N-terminal Flag-GFP-TEV site-Met48 recombinant pig gastric H(+)/K(... | 35604136 |
| Unchecked | IC50 | = | 62000.0 | nM | 4.21 | Inhibition of N-terminal Flag-GFP-TEV site-Met48 recombinant pig gastric H(+)/K(... | 35604136 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35604136 | 10.1021/acs.jmedchem.2c00338 | Unchecked | 17 |
Data from ChEMBL 36 via Core Engine