Assay Detail
Binding
CHEMBL5167556
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal Flag-GFP-TEV site-Met48 recombinant pig gastric H(+)/K(+) ATPase alpha/beta subunit in HEK293 cells by colorimetric microplate reader
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.25 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2079130 | VONOPRAZAN | 4.0 | 1 | 8.82 |
| CHEMBL2105502 | SORAPRAZAN | 2.0 | 1 | 6.52 |
| CHEMBL47529 | — | — | 1 | 5.68 |
| CHEMBL4297583 | TEGOPRAZAN | 3.0 | 1 | 5.64 |
| CHEMBL1618279 | REVAPRAZAN | 2.0 | 1 | 5.64 |
| CHEMBL5208003 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2079130 | VONOPRAZAN | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2105502 | SORAPRAZAN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL47529 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4297583 | TEGOPRAZAN | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1618279 | REVAPRAZAN | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5208003 | — | IC50 | = | 6500.0 | nM | 5.19 |