Compound Detail
CHEMBL2105502
SORAPRAZAN 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL2105502 |
| Name | SORAPRAZAN |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | PWILYDZRJORZDR-MISYRCLQSA-N |
1
Targets
6
Activities
1
Assay Types
0
PK Parameters
2
Publications
1
Known Names
Molecular Properties
367.4
MW (Da)
3.18
ALogP
6
HBA
2
HBD
68.0
PSA (Ų)
0.68
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Activity Summary
IC50 6 meas. best 6.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.54 | 5.9683 | 290.0 | 6 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 290.0 | nM | 6.54 | Inhibition of N-terminal Flag-GFP-TEV site-Met48 recombinant pig gastric H(+)/K(... | 35604136 |
| Unchecked | IC50 | = | 300.0 | nM | 6.52 | Inhibition of N-terminal Flag-GFP-TEV site-Met48 recombinant pig gastric H(+)/K(... | 35604136 |
| Unchecked | IC50 | = | 1100.0 | nM | 5.96 | Inhibition of N-terminal Flag-GFP-TEV site-Met48 recombinant pig gastric H(+)/K(... | 35604136 |
| Unchecked | IC50 | = | 1200.0 | nM | 5.92 | Inhibition of N-terminal Flag-GFP-TEV site-Met48 recombinant pig gastric H(+)/K(... | 35604136 |
| Unchecked | IC50 | = | 3200.0 | nM | 5.5 | Inhibition of N-terminal Flag-GFP-TEV site-Met48 recombinant pig gastric H(+)/K(... | 35604136 |
| Unchecked | IC50 | = | 4300.0 | nM | 5.37 | Inhibition of N-terminal Flag-GFP-TEV site-Met48 recombinant pig gastric H(+)/K(... | 35604136 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35604136 | 10.1021/acs.jmedchem.2c00338 | Unchecked | 17 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
Data from ChEMBL 36 via Core Engine