Assay Detail
Functional
CHEMBL5215573
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 IIIb infected in human MT2 cells assessed as reduction in virus induced cytopathic effect and measured after 5 days by XTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Tailor-made amino acids in the design of small-molecule blockbuster drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.20 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2107825 | TENOFOVIR ALAFENAMIDE | 4.0 | 1 | 8.30 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 5.30 |
| CHEMBL5218696 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2107825 | TENOFOVIR ALAFENAMIDE | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5218696 | — | EC50 | = | 10000.0 | nM | 5.00 |