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Assay Detail

CHEMBL5217402

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]DAMGO from human mu opioid receptor measured after 2 hrs by competitive binding assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Mu-type opioid receptor (CHEMBL233)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Recent Scaffold Hopping Applications in Central Nervous System Drug Discovery.
Callis TB, Garrett TR, Montgomery AP, Danon JJ, Kassiou M.
J Med Chem (2022) 65 : 13483 -13504
PubMed 36206553 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 8.87 8.87

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL596 FENTANYL 4.0 1 8.87

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL596 FENTANYL Ki = 1.35 nM 8.87