Assay Detail
Functional
CHEMBL5217429
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Anticancer activity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 48 hrs by resazurin dye based fluorescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Multiple approaches to repurposing drugs for neuroblastoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.65 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL403183 | — | — | 1 | 6.07 |
| CHEMBL1448 | NICLOSAMIDE | 4.0 | 1 | 6.06 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 6.04 |
| CHEMBL1818132 | — | — | 1 | 5.92 |
| CHEMBL1983268 | ENTRECTINIB | 4.0 | 1 | 5.80 |
| CHEMBL35228 | PYRONARIDINE | 3.0 | 1 | 5.77 |
| CHEMBL5220528 | — | — | 1 | 5.47 |
| CHEMBL314854 | FINGOLIMOD | 4.0 | 1 | 5.33 |
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | 5.07 |
| CHEMBL5219687 | — | — | 1 | 5.01 |
| CHEMBL5219915 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL403183 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL1448 | NICLOSAMIDE | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL1818132 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1983268 | ENTRECTINIB | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL35228 | PYRONARIDINE | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5220528 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL314854 | FINGOLIMOD | IC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL7568 | QUINACRINE | IC50 | = | 8570.0 | nM | 5.07 |
| CHEMBL5219687 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL5219915 | — | IC50 | - | — | - |