Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5217430

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anticancer activity against human SK-N-AS cells assessed as reduction in cell viability incubated for 48 hrs by resazurin dye based fluorescence assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-N-AS
Confidence 1 — Organism
Curated By Autocuration

Target

SK-N-AS (CHEMBL1075578)
Type CELL-LINE
Organism Homo sapiens

Publication

Multiple approaches to repurposing drugs for neuroblastoma.
Rank L, Puhl AC, Havener TM, Anderson E, Foil DH, Zorn KM, Monakhova N, Riabova O, Hickey AJ, Makarov V, Ekins S.
Bioorg Med Chem (2022) 73 : 117043 -117043
PubMed 36208544 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.40 5.91

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL403183 1 5.91
CHEMBL1448 NICLOSAMIDE 4.0 1 5.63
CHEMBL35228 PYRONARIDINE 3.0 1 5.46
CHEMBL1818132 1 5.41
CHEMBL1983268 ENTRECTINIB 4.0 1 5.35
CHEMBL5220528 1 5.27
CHEMBL314854 FINGOLIMOD 4.0 1 5.21
CHEMBL601719 CRIZOTINIB 4.0 1 4.92
CHEMBL5219915 1 -
CHEMBL5219687 1 -
CHEMBL5218687 1 -
CHEMBL588079 1 -
CHEMBL5219722 1 -
CHEMBL5221024 1 -
CHEMBL7568 QUINACRINE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL403183 IC50 = 1230.0 nM 5.91
CHEMBL1448 NICLOSAMIDE IC50 = 2330.0 nM 5.63
CHEMBL35228 PYRONARIDINE IC50 = 3450.0 nM 5.46
CHEMBL1818132 IC50 = 3860.0 nM 5.41
CHEMBL1983268 ENTRECTINIB IC50 = 4470.0 nM 5.35
CHEMBL5220528 IC50 = 5400.0 nM 5.27
CHEMBL314854 FINGOLIMOD IC50 = 6110.0 nM 5.21
CHEMBL601719 CRIZOTINIB IC50 = 12120.0 nM 4.92
CHEMBL5219915 IC50 - -
CHEMBL5219687 IC50 - -
CHEMBL5218687 IC50 - -
CHEMBL588079 IC50 - -
CHEMBL5219722 IC50 - -
CHEMBL5221024 IC50 - -
CHEMBL7568 QUINACRINE IC50 - -