Assay Detail
Functional
CHEMBL5224067
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human THP-1 cells assessed as cell growth inhibition
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Annual review of lysine-specific demethylase 1 (LSD1/KDM1A) inhibitors in 2021.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.23 | 5.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5272643 | — | — | 1 | 5.67 |
| CHEMBL5280652 | — | — | 1 | 5.47 |
| CHEMBL5290883 | — | — | 1 | 5.31 |
| CHEMBL4854446 | — | — | 1 | 5.22 |
| CHEMBL4863608 | — | — | 1 | 5.21 |
| CHEMBL3759201 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5272643 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL5280652 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL5290883 | — | IC50 | = | 4870.0 | nM | 5.31 |
| CHEMBL4854446 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4863608 | — | IC50 | = | 6150.0 | nM | 5.21 |
| CHEMBL3759201 | — | IC50 | = | 33970.0 | nM | 4.47 |