Assay Detail
Binding
CHEMBL5224424
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Inhibition of CDK9/cyclin T1 (unknown origin)
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
CDK9 inhibitors in cancer research.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.70 | 9.00 |
| Ki | 1 | 9.20 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3905910 | VORUCICLIB | 2.0 | 1 | 9.20 |
| CHEMBL3545083 | RGB-286638 | 1.0 | 1 | 9.00 |
| CHEMBL296468 | BMS-387032 | 1.0 | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3905910 | VORUCICLIB | Ki | = | 0.626 | nM | 9.20 |
| CHEMBL3545083 | RGB-286638 | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL296468 | BMS-387032 | IC50 | = | 4.0 | nM | 8.40 |