Assay Detail
Functional
CHEMBL5224706
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity in MDP-stimulated IL-8 production in human THP-1 cells pretreated for 2 hrs followed by MDP stimulation for 6 hrs
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and structure-activity relationship of novel RIPK2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.79 | 8.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4596287 | — | — | 1 | 8.87 |
| CHEMBL5267954 | — | — | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4596287 | — | IC50 | = | 1.34 | nM | 8.87 |
| CHEMBL5267954 | — | IC50 | = | 1.99 | nM | 8.70 |