Assay Detail
Binding
CHEMBL5225131
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human sigma 1 receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships of mixed σ<sub>1</sub>R/σ<sub>2</sub>R ligands with antiproliferative and anticancer effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.57 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4088272 | — | — | 1 | 10.10 |
| CHEMBL190883 | — | — | 1 | 8.96 |
| CHEMBL50112 | — | — | 1 | 8.77 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.60 |
| CHEMBL5270434 | — | — | 1 | 8.51 |
| CHEMBL2170062 | — | — | 1 | 7.77 |
| CHEMBL305881 | — | — | 1 | 7.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4088272 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL190883 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL50112 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL5270434 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL2170062 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL305881 | — | Ki | = | 53.2 | nM | 7.27 |