Assay Detail
Binding
CHEMBL5225133
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [H3]DTG from sigma 1 receptor (unknown origin) by competition binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships of mixed σ<sub>1</sub>R/σ<sub>2</sub>R ligands with antiproliferative and anticancer effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.10 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53325 | — | — | 1 | 9.42 |
| CHEMBL4792070 | — | — | 1 | 8.70 |
| CHEMBL61479 | SIRAMESINE | 2.0 | 1 | 7.98 |
| CHEMBL5274616 | — | — | 1 | 7.54 |
| CHEMBL3984952 | — | — | 1 | 6.87 |
| CHEMBL5273358 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53325 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL4792070 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL61479 | SIRAMESINE | Ki | = | 10.5 | nM | 7.98 |
| CHEMBL5274616 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL3984952 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL5273358 | — | Ki | > | 1000.0 | nM | - |