Assay Detail
Binding
CHEMBL5225142
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to sigma 1 receptor (unknown origin) expressed in human RPMI-8226 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships of mixed σ<sub>1</sub>R/σ<sub>2</sub>R ligands with antiproliferative and anticancer effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.67 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5291247 | — | — | 1 | 8.12 |
| CHEMBL5279451 | — | — | 1 | 7.54 |
| CHEMBL3104857 | — | — | 1 | 7.54 |
| CHEMBL3104856 | — | — | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5291247 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL5279451 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL3104857 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL3104856 | — | Ki | = | 34.0 | nM | 7.47 |