Assay Detail
ADMET
CHEMBL5225679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP2C9 expressed in insect cell microsomes in presence of NADP+ by fluorescence based analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Paltusotine (CRN00808), a Potent, Selective, and Orally Bioavailable Non-peptide SST2 Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.15 | 5.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5276605 | — | — | 1 | 5.20 |
| CHEMBL5267842 | PALTUSOTINE | 3.0 | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5276605 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL5267842 | PALTUSOTINE | IC50 | = | 7943.28 | nM | 5.10 |