Assay Detail
Binding
CHEMBL5226917
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human beta-catenin (142 to 686 residues)/human TCF (7 to 51 residues) protein-protein interaction incubated for 3 hrs by fluorescence polarization assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SW480 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Catenin beta-1/Transcription factor 7 (CHEMBL3885542) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
A perspective on medicinal chemistry approaches towards adenomatous polyposis coli and Wnt signal based colorectal cancer inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.50 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5285142 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5285142 | — | IC50 | = | 3140.0 | nM | 5.50 |