Assay Detail
Functional
CHEMBL5227450
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Antiinflammatory activity in human THP-1 cells assessed as inhibition of LPS-stimulated TNFalpha production
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Fused-azepinones: Emerging scaffolds of medicinal importance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.47 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361708 | HYMENIALDISINE | — | 1 | 5.85 |
| CHEMBL481333 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361708 | HYMENIALDISINE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL481333 | — | IC50 | = | 8200.0 | nM | 5.09 |