Assay Detail
Binding
CHEMBL5228256
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Nurr1-RXRalpha in HEK293T cells by BRET assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha (CHEMBL3885613) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Targeting Nuclear Receptors in Neurodegeneration and Neuroinflammation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 8.30 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1023 | BEXAROTENE | 4.0 | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1023 | BEXAROTENE | EC50 | = | 5.012 | nM | 8.30 |