Assay Detail
Binding
CHEMBL5228433
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to his tagged EED (1 to 441 residues) (unknown origin) incubated for 20 mins in presence of biotinylated H3K27me3 peptide (19 to 33 residues) by alphascreen competitive binding assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Polycomb Repressive Complex 2 Modulation through the Development of EZH2-EED Interaction Inhibitors and EED Binders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.42 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5268403 | — | — | 1 | 8.35 |
| CHEMBL4755618 | — | — | 1 | 8.23 |
| CHEMBL5283723 | — | — | 1 | 6.50 |
| CHEMBL4097892 | — | — | 1 | 6.05 |
| CHEMBL4074159 | — | — | 1 | 5.80 |
| CHEMBL5282599 | — | — | 1 | 5.06 |
| CHEMBL5269781 | — | — | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5268403 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4755618 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL5283723 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4097892 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4074159 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL5282599 | — | IC50 | = | 8760.0 | nM | 5.06 |
| CHEMBL5269781 | — | IC50 | = | 11580.0 | nM | 4.94 |