Compound Detail
CHEMBL5269781
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Basic Information
| ChEMBL ID | CHEMBL5269781 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LVLOUZWLCDLTGX-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
429.5
MW (Da)
4.25
ALogP
7
HBA
1
HBD
89.5
PSA (Ų)
0.67
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.94
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Polycomb protein EED CHEMBL2189117 | IC50 | 4.94 | 4.94 | 11580.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Polycomb protein EED | IC50 | = | 11580.0 | nM | 4.94 | Binding affinity to his tagged EED (1 to 441 residues) (unknown origin) incubate... | 34351144 |
| Polycomb protein EED | IC50 | = | 11580.0 | nM | 4.94 | Binding affinity to his tagged EED (1 to 441 residues) (unknown origin) incubate... | 35224495 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34351144 | 10.1021/acs.jmedchem.1c00226 | Polycomb protein EED | 1 |
| 35224495 | 10.1039/d1md00274k | Polycomb protein EED | 1 |
Data from ChEMBL 36 via Core Engine