Assay Detail
Binding
CHEMBL5237690
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to his tagged EED (1 to 441 residues) (unknown origin) incubated for 20 mins in presence of biotinylated H3K27me3 peptide (19 to 33 residues) by alphascreen competitive binding assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An overview of the development of EED inhibitors to disable the PRC2 function.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.67 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4096234 | — | — | 1 | 6.50 |
| CHEMBL4097892 | — | — | 1 | 6.05 |
| CHEMBL4074159 | — | — | 1 | 5.80 |
| CHEMBL5273243 | — | — | 1 | 5.06 |
| CHEMBL5269781 | — | — | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4096234 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4097892 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4074159 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL5273243 | — | IC50 | = | 8760.0 | nM | 5.06 |
| CHEMBL5269781 | — | IC50 | = | 11580.0 | nM | 4.94 |