Assay Detail
Binding
CHEMBL5228481
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Inhibition of ROCK1 (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Emerging targets in drug discovery against neurodegenerative diseases: Control of synapsis disfunction by the RhoA/ROCK pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.86 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1971943 | BAY-549 | — | 1 | 9.22 |
| CHEMBL5287991 | — | — | 1 | 8.91 |
| CHEMBL220241 | GSK-269962A | — | 1 | 8.80 |
| CHEMBL571948 | Y-39983 | 1.0 | 1 | 8.44 |
| CHEMBL5266198 | — | — | 1 | 7.72 |
| CHEMBL1233300 | HYDROXYFASUDIL | — | 1 | 6.14 |
| CHEMBL5278924 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1971943 | BAY-549 | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5287991 | — | IC50 | = | 1.22 | nM | 8.91 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL571948 | Y-39983 | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL5266198 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1233300 | HYDROXYFASUDIL | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL5278924 | — | IC50 | = | 1590.0 | nM | 5.80 |