Assay Detail
Binding
CHEMBL5229242
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Mycobacterium tuberculosis partial length PknB (M1 to G279 residues) expressed in mammalian expression system by KdELECT kinase assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase PknB (CHEMBL1908385) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Engineering Selectivity for Reduced Toxicity of Bacterial Kinase Inhibitors Using Structure-Guided Medicinal Chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 7.15 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5282194 | — | — | 1 | 7.72 |
| CHEMBL468963 | GW779439X | — | 1 | 7.58 |
| CHEMBL5283441 | — | — | 1 | 7.33 |
| CHEMBL5283041 | — | — | 1 | 6.75 |
| CHEMBL5283475 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5282194 | — | Kd | = | 19.0 | nM | 7.72 |
| CHEMBL468963 | GW779439X | Kd | = | 26.0 | nM | 7.58 |
| CHEMBL5283441 | — | Kd | = | 47.0 | nM | 7.33 |
| CHEMBL5283041 | — | Kd | = | 180.0 | nM | 6.75 |
| CHEMBL5283475 | — | Kd | = | 430.0 | nM | 6.37 |