Assay Detail
Binding
CHEMBL5229867
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS-CoV-2 MPro
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Identification of Natural Products Inhibiting SARS-CoV-2 by Targeting Viral Proteases: A Combined in Silico and in Vitro Approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.74 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8260 | BAICALEIN | 2.0 | 1 | 6.01 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.80 |
| CHEMBL403516 | ACETYLSHIKONIN | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8260 | BAICALEIN | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL403516 | ACETYLSHIKONIN | IC50 | = | 3800.0 | nM | 5.42 |