Assay Detail
Binding
CHEMBL5231380
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Inhibition of KDM5B (unknown origin)
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting histone demethylase KDM5B for cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.84 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4454253 | — | — | 1 | 8.52 |
| CHEMBL3787669 | — | — | 1 | 8.40 |
| CHEMBL5285949 | — | — | 1 | 8.40 |
| CHEMBL5277258 | — | — | 1 | 8.15 |
| CHEMBL5285505 | — | — | 1 | 8.05 |
| CHEMBL5277129 | — | — | 1 | 8.05 |
| CHEMBL5274997 | — | — | 1 | 8.00 |
| CHEMBL5290962 | — | — | 1 | 7.77 |
| CHEMBL4078388 | — | — | 1 | 7.72 |
| CHEMBL5268579 | — | — | 1 | 7.31 |
| CHEMBL3786593 | — | — | 1 | 7.31 |
| CHEMBL5269187 | — | — | 1 | 7.19 |
| CHEMBL5279892 | — | — | 1 | 7.01 |
| CHEMBL5276370 | — | — | 1 | 6.74 |
| CHEMBL5268613 | — | — | 1 | 6.69 |
| CHEMBL5269420 | — | — | 1 | 6.57 |
| CHEMBL3188597 | — | — | 1 | 5.77 |
| CHEMBL145 | CAFFEIC ACID | 3.0 | 1 | 5.54 |
| CHEMBL1336959 | — | — | 1 | 5.52 |
| CHEMBL244743 | ESCULETIN | — | 1 | 5.34 |
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 5.30 |
| CHEMBL1982368 | — | — | 1 | 5.30 |
| CHEMBL3183531 | — | — | 1 | 5.01 |
| CHEMBL90852 | N-OXALYLGLYCINE | — | 1 | 4.61 |
| CHEMBL1794791 | OXALOACETATE | 2.0 | 1 | - |
| CHEMBL576 | SUCCINIC ACID | 3.0 | 1 | - |
| CHEMBL1261 | CITRIC ACID | 4.0 | 1 | - |
| CHEMBL1615211 | — | — | 1 | - |
| CHEMBL1614745 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4454253 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3787669 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5285949 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5277258 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5285505 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5277129 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5274997 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5290962 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4078388 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5268579 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3786593 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL5269187 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5279892 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL5276370 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL5268613 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL5269420 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3188597 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL145 | CAFFEIC ACID | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL1336959 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL244743 | ESCULETIN | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL51085 | EBSELEN | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1982368 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3183531 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL90852 | N-OXALYLGLYCINE | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL1794791 | OXALOACETATE | IC50 | = | 900000.0 | nM | - |
| CHEMBL576 | SUCCINIC ACID | IC50 | = | 1400000.0 | nM | - |
| CHEMBL1261 | CITRIC ACID | IC50 | = | 800000.0 | nM | - |
| CHEMBL1615211 | — | IC50 | = | 1600000.0 | nM | - |
| CHEMBL1614745 | — | IC50 | = | 3600000.0 | nM | - |