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Assay Detail

CHEMBL5231933

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiparasitic activity against Giardia lamblia P15 WB assessed a inhibition of parasitic growth incubated for 48 hrs by cell titer glo-based luminescence assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Giardia intestinalis
Confidence 1 — Organism
Curated By Autocuration

Target

Giardia intestinalis (CHEMBL612652)
Type ORGANISM
Organism Giardia intestinalis

Publication

Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility.
Ang CW, Tan L, Sykes ML, AbuGharbiyeh N, Debnath A, Reid JC, West NP, Avery VM, Cooper MA, Blaskovich MAT.
J Med Chem (2020) 63 : 15726 -15751
PubMed 33151678 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.20 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5273984 1 6.30
CHEMBL4473101 1 5.77
CHEMBL5178306 1 5.75
CHEMBL5279016 1 5.62
CHEMBL227875 PRETOMANID 4.0 1 5.52
CHEMBL4580019 1 5.46
CHEMBL5172550 1 5.30
CHEMBL4453399 1 5.30
CHEMBL5283670 1 5.15
CHEMBL5271296 1 4.75
CHEMBL5282691 1 4.72
CHEMBL5196011 1 4.43
CHEMBL5283189 1 4.40
CHEMBL5272514 1 4.30
CHEMBL5284681 1 -
CHEMBL5269176 1 -
CHEMBL5266915 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5273984 IC50 = 500.0 nM 6.30
CHEMBL4473101 IC50 = 1700.0 nM 5.77
CHEMBL5178306 IC50 = 1800.0 nM 5.75
CHEMBL5279016 IC50 = 2400.0 nM 5.62
CHEMBL227875 PRETOMANID IC50 = 3000.0 nM 5.52
CHEMBL4580019 IC50 = 3500.0 nM 5.46
CHEMBL5172550 IC50 = 5000.0 nM 5.30
CHEMBL4453399 IC50 = 5000.0 nM 5.30
CHEMBL5283670 IC50 = 7100.0 nM 5.15
CHEMBL5271296 IC50 = 18000.0 nM 4.75
CHEMBL5282691 IC50 = 19000.0 nM 4.72
CHEMBL5196011 IC50 = 37000.0 nM 4.43
CHEMBL5283189 IC50 = 40000.0 nM 4.40
CHEMBL5272514 IC50 = 50000.0 nM 4.30
CHEMBL5284681 IC50 > 50000.0 nM -
CHEMBL5269176 IC50 > 23000.0 nM -
CHEMBL5266915 IC50 > 50000.0 nM -